Minnelide

For research use only. Not for therapeutic Use.

  • CAT Number: I018728
  • CAS Number: 1254702-87-8
  • Molecular Formula: C₂₁H₂₅Na₂O₁₀P
  • Molecular Weight: 514.37
  • Purity: ≥95%
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Minnelide (Cat No.:I018728) is a synthetic prodrug derived from triptolide, a natural compound found in the Thunder God Vine. Minnelide has shown potent anticancer activity in preclinical studies, targeting multiple signaling pathways involved in cancer cell growth and survival. It has demonstrated efficacy against various cancer types, including pancreatic cancer, in both in vitro and in vivo models. Minnelide’s mechanism of action involves inhibiting NF-κB and HSP70, resulting in tumor cell death and suppression of tumor growth.


Catalog Number I018728
CAS Number 1254702-87-8
Molecular Formula C₂₁H₂₅Na₂O₁₀P
Purity ≥95%
Target Apoptosis
Storage Store at -20°C
IUPAC Name disodium;[(1S,2S,4S,5S,7S,8R,9R,11S,13S)-1-methyl-17-oxo-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-8-yl]oxymethyl phosphate
InChI InChI=1S/C21H27O10P.2Na/c1-9(2)19-14(30-19)15-21(31-15)18(3)5-4-10-11(7-26-16(10)22)12(18)6-13-20(21,29-13)17(19)27-8-28-32(23,24)25;;/h9,12-15,17H,4-8H2,1-3H3,(H2,23,24,25);;/q;2*+1/p-2/t12-,13-,14-,15-,17+,18-,19-,20+,21+;;/m0../s1
InChIKey ZHBJMVNZRZUQEP-KIKMAQITSA-L
SMILES CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2OCOP(=O)([O-])[O-])O7)COC6=O)C.[Na+].[Na+]
Reference

[1]. Noel P, et al. Triptolide and Its Derivatives as Cancer Therapies. Trends Pharmacol Sci. 2019 May;40(5):327-341.<br>[2]. Chugh R, et al. A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med. 2012 Oct 17;4(156):156ra139.

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