For research use only. Not for therapeutic Use.
Minocycline（Cat No.:M122344）is a broad-spectrum tetracycline antibiotic widely used to treat bacterial infections such as acne, respiratory tract infections, and certain sexually transmitted infections. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the addition of amino acids to the growing peptide chain. Minocycline also exhibits anti-inflammatory and neuroprotective properties, making it a candidate for research into neurodegenerative diseases and autoimmune conditions. Its broad activity, including effectiveness against resistant bacterial strains, highlights its importance in both clinical applications and scientific research on antimicrobial and anti-inflammatory therapies.
| Catalog Number | M122344 |
| CAS Number | 10118-90-8 |
| Molecular Formula | C23H27N3O7 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | -20°C |
| IUPAC Name | (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide |
| InChI | InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1 |
| InChIKey | FFTVPQUHLQBXQZ-KVUCHLLUSA-N |
| SMILES | CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C |
| Reference | The 6-deoxytetracyclines. VII. Alkylated aminotetracyclines possessing unique antibacterial activity. Martel M.J. & Boothe J.H. J. Med. Chem. 1967, 10, 44.<br/><br/>Synthesis of 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) via 9-nitro-6-demethyl-6-deoxytetracycline. Church R.F.R. et al. J. Org. Chem. 1971, 36, 723.</span></p> |
