Minoxidil

For research use only. Not for therapeutic Use.

  • CAT Number: A000597
  • CAS Number: 38304-91-5
  • Molecular Formula: C9H15N5O
  • Molecular Weight: 209.3
  • Purity: ≥95%
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Minoxidil(Cat No.:A000597), is a medication primarily used to treat male and female pattern baldness (androgenetic alopecia). It is available in topical form as a solution or foam and is applied directly to the scalp. Minoxidil works by promoting hair growth and preventing hair loss by dilating blood vessels, increasing blood flow to hair follicles, and potentially prolonging the anagen (growth) phase of hair. While it can slow hair loss and promote regrowth in some individuals, its effectiveness varies from person to person. Minoxidil has been a popular over-the-counter treatment for hair loss and is available in various brand-name products.


Catalog Number A000597
CAS Number 38304-91-5
Synonyms

38304-91-5; Rogaine; Loniten; Regaine; Minoximen

Molecular Formula C9H15N5O
Purity ≥95%
Target Metabolic Enzyme/Protease
Solubility Limited solubility
Storage 2-8°C
IUPAC Name 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
InChI InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChIKey ZIMGGGWCDYVHOY-UHFFFAOYSA-N
SMILES C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
Reference

1: Forrester MB. Pediatric Minoxidil Exposures Reported to Texas Poison Centers.
Pediatr Emerg Care. 2017 Jul 3. doi: 10.1097/PEC.0000000000001226. [Epub ahead of
print] PubMed PMID: 29112111.
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2: Tricarico D, Maqoud F, Curci A, Camerino G, Zizzo N, Denora N, Cutrignelli A,
Laquintana V, Lopalco A, la Forgia F, Fontana S, Franco M, Lopedota A.
Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in
aqueous alginate gel useful for alopecia management: Efficacy evaluation in male
rat. Eur J Pharm Biopharm. 2017 Oct 24. pii: S0939-6411(17)30705-1. doi:
10.1016/j.ejpb.2017.10.015. [Epub ahead of print] PubMed PMID: 29079420.
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3: Lee JH, Park HN, Park HJ, Kim NS, Park SK, Lee J, Baek SY. Isolation and
structural identification of a novel minoxidil analogue in an illegal dietary
supplement: triaminodil. Food Addit Contam Part A Chem Anal Control Expo Risk
Assess. 2017 Nov 7:1-8. doi: 10.1080/19440049.2017.1397295. [Epub ahead of print]
PubMed PMID: 29067865.
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4: Dhurat R, Chitallia J, May TW, Jayaraaman AM, Madhukara J, Anandan S, Vaidya
P, Klenk A. An Open-Label Randomized Multicenter Study Assessing the
Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5%
Solution in Male Androgenetic Alopecia. Skin Pharmacol Physiol. 2017 Oct
21;30(6):298-305. doi: 10.1159/000481141. [Epub ahead of print] PubMed PMID:
29055953.
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5: Bao L, Gong L, Guo M, Liu T, Shi A, Zong H, Xu X, Chen H, Gao X, Li Y.
Randomized trial of electrodynamic microneedle combined with 5% minoxidil topical
solution for the treatment of Chinese male Androgenetic alopecia. J Cosmet Laser
Ther. 2017 Oct 13. doi: 10.1080/14764172.2017.1376094. [Epub ahead of print]
PubMed PMID: 29028377.
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6: Lee HJ, Oh DW, Na MJ, Kim DW, Yuk DY, Choi HC, Lee YB, Han K, Park CW.
Preparation and in vivo evaluation of lecithin-based microparticles for topical
delivery of minoxidil. Arch Pharm Res. 2017 Aug 2. doi:
10.1007/s12272-017-0934-x. [Epub ahead of print] PubMed PMID: 28770536.

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7: Shah KB, Shah AN, Solanki RB, Raval RC. A Comparative Study of Microneedling
with Platelet-rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%)
Alone in Androgenetic Alopecia. Int J Trichology. 2017 Jan-Mar;9(1):14-18. doi:
10.4103/ijt.ijt_75_16. PubMed PMID: 28761259; PubMed Central PMCID: PMC5514790.

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8: Siavash M, Tavakoli F, Mokhtari F. Comparing the Effects of Zinc Sulfate,
Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on
Controlling Hair Loss in Women: A Randomized Controlled Trial. J Res Pharm Pract.
2017 Apr-Jun;6(2):89-93. doi: 10.4103/jrpp.JRPP_17_17. PubMed PMID: 28616431;
PubMed Central PMCID: PMC5463555.

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9: Stamatas GN, Wu J, Pappas A, Mirmirani P, McCormick TS, Cooper KD, Consolo M,
Schastnaya J, Ozerov IV, Aliper A, Zhavoronkov A. An analysis of gene expression
data involving examination of signaling pathways activation reveals new insights
into the mechanism of action of minoxidil topical foam in men with androgenetic
alopecia. Cell Cycle. 2017;16(17):1578-1584. doi: 10.1080/15384101.2017.1327492.
Epub 2017 Jun 8. PubMed PMID: 28594262; PubMed Central PMCID: PMC5587030.
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10: Wehner MR, Nead KT, Lipoff JB. Association Between Gender and Drug Cost for
Over-the-Counter Minoxidil. JAMA Dermatol. 2017 Aug 1;153(8):825-826. doi:
10.1001/jamadermatol.2017.1394. PubMed PMID: 28593214.

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