Mirabegron

• CAT Number: A000253
• CAS Number: 223673-61-8
• Molecular Formula: C21H24N4O2S
• Molecular Weight: 396.5
• Purity: ≥95%
• Synonyms: 223673-61-8; Myrbetriq; UNII-MVR3JL3B2V; YM 178; YM-178
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• IUPAC Name: 2-(2-amino-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]acetamide
• InChI: 1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
• InChIKey: PBAPPPCECJKMCM-IBGZPJMESA-N
• SMILES: C1=CC=C(C=C1)C(CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O

Mirabegron (YM-178, trade name Myrbetriq, CAS 223673-61-8 ) is a drug for the treatment of overactive bladder. It was developed by Astellas Pharma and was approved in the United States in July 2012. Mirabegron activates the β3 adrenergic receptor in the detrusor muscle in the bladder, which leads to muscle relaxation and an increase in bladder capacity.

Overview of Clinical Research

Mirabegron is a beta 3 adrenergic receptor agonist developed by Astellas Pharma and Johns Hopkins University. The Phase III clinical trials in Overactive bladder begins in 2020. 

Reference

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2: Gibson W, MacDiarmid S, Huang M, Siddiqui E, Stölzel M, Choudhury N, Drake MJ. Treating Overactive Bladder in Older Patients with a Combination of Mirabegron and Solifenacin: A Prespecified Analysis from the BESIDE Study. Eur Urol Focus. 2017 Sep 12. pii: S2405-4569(17)30200-6. doi: 10.1016/j.euf.2017.08.008. [Epub ahead of print] PubMed PMID: 28916436.
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7: Kato D, Tabuchi H, Uno S. Safety, Efficacy, and Persistence of Long-Term Mirabegron Treatment for Overactive Bladder in the Daily Clinical Setting: Interim (1-Year) Report from a Japanese Post-Marketing Surveillance Study. Low Urin Tract Symptoms. 2017 Aug 1. doi: 10.1111/luts.12188. [Epub ahead of print] PubMed PMID: 28762672.
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