For research use only. Not for therapeutic Use.
Miransertib（Cat No.:I001203）, also known as ARQ-092, is a highly potent and selective allosteric inhibitor of Akt. It is orally bioavailable and demonstrates remarkable inhibitory activity against all three isoforms of Akt. The IC50 values for Miransertib are 2.7 nM, 14 nM, and 8.1 nM for Akt1, Akt2, and Akt3, respectively. By targeting Akt, a key signaling protein involved in cell growth and survival, Miransertib holds potential as a therapeutic agent in various diseases, including cancer, where dysregulation of Akt signaling is implicated.
| Catalog Number | I001203 |
| CAS Number | 1313881-70-7 |
| Synonyms | 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-2-pyridinamine |
| Molecular Formula | C₂₇H₂₄N₆ |
| Purity | ≥95% |
| Target | Akt |
| Solubility | DMSO: ＞ 40 mg/mL |
| Storage | -20°C |
| IUPAC Name | 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine |
| InChI | InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30) |
| InChIKey | HNFMVVHMKGFCMB-UHFFFAOYSA-N |
| SMILES | C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N |
| Reference | <p style=/line-height:25px/> |
