For research use only. Not for therapeutic Use.
Misoprostol is a prostaglandin E<sub>1</sub> (Item No. <span class=/itemid/>13010</span>) analog with agonist activity mediated by EP<sub>2</sub>, EP<sub>3</sub>, and EP<sub>4</sub> receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED<sub>50</sub> = 0.31 µg/kg), inhibit superoxide generation in human neutrophils (EC<sub>50</sub> = 0.35 µM), and relax fetal rabbit ductus arteriosus (EC<sub>50</sub> = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-<wbr></wbr>486; Item No. <span class=/itemid/>10006317</span>) for the oral induction of first trimester abortion. Misoprostol contains a C-<wbr></wbr>1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.
| Catalog Number | R008464 |
| CAS Number | 112137-89-0 |
| Synonyms | (11α,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic Acid; Misoprostol Free Acid; (+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E1; |
| Molecular Formula | C21H36O5 |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Storage | -20°C |
| InChIKey | CNWGPXZGIIOYDL-MKYGPDKMSA-N |
