Mito-TEMPO

• CAT Number: I019745
• CAS Number: 1334850-99-5
• Molecular Formula: C₂₉H₃₅ClN₂O₂P
• Molecular Weight: 510.03
• Purity: ≥95%
• Target: NF-κB
• IUPAC Name: [2-[(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium;chloride
• InChI: InChI=1S/C29H35N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23,33H,20-22H2,1-4H3;1H
• InChIKey: QJEOOHMMSUBNGG-UHFFFAOYSA-N
• SMILES: CC1(CC(CC(N1O)(C)C)NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Cl-]

Mito-TEMPO(CAT: I019745) is a mitochondria-targeted antioxidant widely utilized in oxidative stress and mitochondrial research. It consists of a conjugation between the antioxidant TEMPO (2,2,6,6-tetramethylpiperidine-N-oxyl) and a lipophilic triphenylphosphonium (TPP) cation, allowing it to accumulate selectively within mitochondria. Mito-TEMPO effectively scavenges reactive oxygen species (ROS), such as superoxide, and is valuable for studying mitochondrial dysfunction in conditions like neurodegenerative diseases, cardiovascular disorders, and aging. Researchers use it to investigate the role of mitochondrial oxidative stress in cellular signaling and pathophysiology. With its high specificity and targeted action, Mito-TEMPO is an essential tool for advancing mitochondrial biology and therapeutic research.