For research use only. Not for therapeutic Use.
MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1].<br>MB-10 (100 μM) is a potential attenuator of protein import into mitochondria[1].
MB-10 inhibits the import of substrates that use the TIM23 import pathway[1].
MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria[1].
| Catalog Number | I015048 |
| CAS Number | 394694-98-5 |
| Molecular Formula | C₁₂H₈FN₃O₃S |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Reference | [1]. Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442. |
