MitoBloCK-10

• CAT Number: I015048
• CAS Number: 394694-98-5
• Molecular Formula: C₁₂H₈FN₃O₃S
• Molecular Weight: 293.27
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• IUPAC Name: 3-fluoro-N-[(E)-(5-nitrothiophen-2-yl)methylideneamino]benzamide
• InChI: InChI=1S/C12H8FN3O3S/c13-9-3-1-2-8(6-9)12(17)15-14-7-10-4-5-11(20-10)16(18)19/h1-7H,(H,15,17)/b14-7+
• InChIKey: QDYQZMWFIYLMNX-VGOFMYFVSA-N
• SMILES: C1=CC(=CC(=C1)F)C(=O)N/N=C/C2=CC=C(S2)[N+](=O)[O-]

MitoBloCK-10 (CAT: I015048) is the first small-molecule modulator shown to attenuate the activity of the protein-associated motor (PAM) complex, a critical component of the mitochondrial import machinery. By disrupting the PAM complex, MB-10 impairs the translocation of proteins into the mitochondrial matrix, affecting mitochondrial function and homeostasis. This compound is particularly valuable in mitochondrial biology and cellular metabolism research, enabling studies on protein import mechanisms, mitochondrial dynamics, and their roles in health and disease. MitoBloCK-10 is a pioneering tool for exploring mitochondrial dysfunction and its therapeutic implications in neurodegenerative diseases, metabolic disorders, and cancer.