For research use only. Not for therapeutic Use.
MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs[1].
| Catalog Number | I045519 |
| CAS Number | 303215-67-0 |
| Synonyms | 2-[(4-anilinophenyl)iminomethyl]-4,6-dichlorophenol |
| Molecular Formula | C19H14Cl2N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H14Cl2N2O/c20-14-10-13(19(24)18(21)11-14)12-22-15-6-8-17(9-7-15)23-16-4-2-1-3-5-16/h1-12,23-24H |
| InChIKey | DBYOPSAQYAKIQV-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)NC2=CC=C(C=C2)N=CC3=C(C(=CC(=C3)Cl)Cl)O |
| Reference | [1]. Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92. |
