Mitochondria degrader-1

• CAT Number: I043526
• CAS Number: 2241669-05-4
• Molecular Formula: C33H49ClFN7O8S
• Molecular Weight: 758.30
• Purity: ≥95%
• Synonyms: (2R)-2-acetamido-3-[[2-amino-9-[(4-fluorophenyl)methyl]-6-oxo-1H-purin-8-yl]sulfanyl]-N-[2-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]propanamide
• InChI: InChI=1S/C33H49ClFN7O8S/c1-24(43)38-27(23-51-33-39-28-29(40-32(36)41-31(28)45)42(33)22-25-6-8-26(35)9-7-25)30(44)37-11-13-47-15-17-49-19-21-50-20-18-48-16-14-46-12-5-3-2-4-10-34/h6-9,27H,2-5,10-23H2,1H3,(H,37,44)(H,38,43)(H3,36,40,41,45)/t27-/m0/s1
• InChIKey: JIUOEUKVQTVYRY-MHZLTWQESA-N
• SMILES: CC(=O)N[C@@H](CSC1=NC2=C(N1CC3=CC=C(C=C3)F)N=C(NC2=O)N)C(=O)NCCOCCOCCOCCOCCOCCCCCCCl

Mitochondria degrader-1（Cat No.:I043526）is a small-molecule compound designed to selectively target and degrade dysfunctional mitochondria through the process of mitophagy. By promoting the clearance of damaged mitochondria, it helps restore cellular homeostasis and reduce oxidative stress, which is implicated in various diseases, including neurodegenerative disorders, cancer, and metabolic syndromes. Mitochondria degrader-1 functions by recruiting components of the autophagy machinery to mitochondria, initiating their breakdown and removal. This targeted degradation approach offers therapeutic potential for conditions associated with mitochondrial dysfunction and is a valuable tool for studying mitochondrial quality control pathways in cellular biology.