MitoNeoD

For research use only. Not for therapeutic Use.

  • CAT Number: I032364
  • CAS Number: 2375088-89-2
  • Molecular Formula: C53H62DBrN3P
  • Molecular Weight: 853.9919
  • Purity: 95%
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MitoNeoD is a novel mitochondria-targeted O2(⋅−) probe that can be used in vivo. It prevents DNA intercalation. MitoNeoD incorporates a carbon-deuterium bond, and enhances O2(⋅−) selectivity. MitoNeoD comprises a O2⋅–sensitive reduced phenanthridinium moiety modified to prevent DNA intercalation, as well as a carbon-deuterium bond to enhance its selectivity for O2⋅- over non-specific oxidation, and a triphenylphosphonium lipophilic cation moiety leading to the rapid accumulation within mitochondria. MitoNeoD is a versatile and robust probe to assess changes in mitochondrial O2⋅- from isolated mitochondria to animal models, thus offering a way to examine the many roles of mitochondrial O2⋅- production in health and disease.


Catalog Number I032364
CAS Number 2375088-89-2
Synonyms

MitoNeoD; Mito-NeoD; Mito Neo D; Mito-Neo-D; Mito Neo-D

Molecular Formula C53H62DBrN3P
Purity 95%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (6-(3,8-Bis(neopentylamino)-6-phenylphenanthridin-5(6H)-yl-6-d)hexyl)triphenylphosphonium bromide
InChI InChI=1S/C53H63N3P.BrH/c1-52(2,3)39-54-42-31-33-47-48-34-32-43(55-40-53(4,5)6)38-50(48)56(51(49(47)37-42)41-23-13-9-14-24-41)35-21-7-8-22-36-57(44-25-15-10-16-26-44,45-27-17-11-18-28-45)46-29-19-12-20-30-46;/h9-20,23-34,37-38,51,54-55H,7-8,21-22,35-36,39-40H2,1-6H3;1H/q+1;/p-1/i51D;
InChIKey FMTMQUAQVIOWNQ-UTANGQNASA-M
SMILES CC(C)(C)CNC1=CC(C(C2=CC=CC=C2)([2H])N(CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC(NCC(C)(C)C)=CC=C76)=C7C=C1.[Br-]
Reference

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