MitoPQ

• CAT Number: I007999
• CAS Number: 1821370-28-8
• Molecular Formula: C39H46I3N2P
• Molecular Weight: 954.48
• Purity: ≥95%
• Synonyms: 10-[4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]decyl-triphenylphosphanium;triiodide
• InChI: InChI=1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39;;;/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3;3*1H/q+3;;;/p-3
• InChIKey: AOZZGHKENAZYTD-UHFFFAOYSA-K
• SMILES: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]

MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study[1].
MitoPQ (5 μM, 0.5 s-20 min) increases MitoSOX fluorescence in dose- and time-dependently manner in C2C12 myoblasts[1].
MitoPQ (1-10 μM, 6 h) increases MnSOD expression at the dose of 1-5 μM and decreases MnSOD expression at the dose of 10 μM in C2C12 myoblasts[1].
MitoPQ (1-10 μM, 24 h) increased HCT-116 cell death[1].

Reference

[1]. Robb EL, et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radic Biol Med. 2015 Dec;89:883-94.
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