MitoTam iodide, hydriodide

• CAT Number: I018705
• CAS Number: 1634624-74-0
• Molecular Formula: C₅₂H₆₀I₂NOP
• Molecular Weight: 999.82
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• Storage: Store at -20°C
• IUPAC Name: [(Z)-12-[4-[2-(dimethylamino)ethoxy]phenyl]-11,12-diphenyldodec-11-enyl]-triphenylphosphanium;iodide;hydroiodide
• InChI: InChI=1S/C52H59NOP.2HI/c1-53(2)41-42-54-47-39-37-46(38-40-47)52(45-28-16-10-17-29-45)51(44-26-14-9-15-27-44)36-24-7-5-3-4-6-8-25-43-55(48-30-18-11-19-31-48,49-32-20-12-21-33-49)50-34-22-13-23-35-50;;/h9-23,26-35,37-40H,3-8,24-25,36,41-43H2,1-2H3;2*1H/q+1;;/p-1/b52-51-
• InChIKey: LVHTWQRJWNCPET-DRFCFMONSA-M
• SMILES: CN(C)CCOC1=CC=C(C=C1)C(=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=CC=C6.I.[I-]

MitoTam iodide, hydriodide（Cat No.:I018705） is a derivative of tamoxifen, which is a known selective estrogen receptor modulator. It acts as an inhibitor of the electron transport chain (ETC) within mitochondria. This compound has been found to reduce the mitochondrial membrane potential in senescent cells and has an impact on mitochondrial morphology. By affecting these mitochondrial parameters, MitoTam iodide, and hydriodide may have implications for cellular aging and related processes.

Reference

[1]. Rohlenova K, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2highBreast Cancer. Antioxid Redox Signal. 2017 Jan 10;26(2):84-103.[2]. Hubackova S, et al. Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2. Cell Death Differ. 2019 Jan;26(2):276-290.