Mitotane

• CAT Number: A000369
• CAS Number: 53-19-0
• Molecular Formula: C14H10Cl4
• Molecular Weight: 320
• Purity: ≥95%
• Synonyms: Mitotan; Lysodren; 53-19-0; Chlodithane; Chloditan
• Target: Apoptosis
• Storage: -20°C
• InChI: 1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
• InChIKey: JWBOIMRXGHLCPP-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl

Mitotane is a synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production.

Reference

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