Mitotane

• CAT Number: A000369
• CAS Number: 53-19-0
• Molecular Formula: C14H10Cl4
• Molecular Weight: 320.04
• Purity: ≥95%
• Synonyms: Mitotan; Lysodren; 53-19-0; Chlodithane; Chloditan
• Target: Apoptosis
• Storage: -20°C
• IUPAC Name: 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
• InChI: 1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
• InChIKey: JWBOIMRXGHLCPP-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl

Mitotane (Cat No.:A000369) is a drug used primarily in the treatment of adrenocortical carcinoma (ACC), a rare form of cancer affecting the adrenal glands. It works by inhibiting the production of adrenal hormones and disrupting the function of adrenal cells, leading to tumor cell death. Mitotane is often used in combination with surgery or radiation therapy, particularly for advanced or metastatic ACC. However, it can cause side effects like adrenal insufficiency, gastrointestinal issues, and neurotoxicity, requiring careful monitoring during treatment.

Reference

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