Mitoxantrone-d8

• CAT Number: R006160
• CAS Number: 1189974-82-0
• Molecular Formula: C22H28N4O6
• Molecular Weight: 452.537
• Purity: ≥95%
• Synonyms: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl-d4)amino]ethyl]amino]-9,10-anthracenedione; 1,4-Bis[(2-(2-hydroxyethylamino-d4)ethyl)amino]-5,8-dihydroxyanthraquinone; DHAQ-d8; Dihydroxyanthraquinone-d8; Mitox-d8; Mitoxanthrone-d8; Mitozantrone-d8; Nimitox
• Storage: Store at RT
• IUPAC Name: 1,4-dihydroxy-5,8-bis[2-[(1,1,2,2-tetradeuterio-2-hydroxyethyl)amino]ethylamino]anthracene-9,10-dione
• InChI: InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2/i9D2,10D2,11D2,12D2
• InChIKey: KKZJGLLVHKMTCM-PMCMNDOISA-N
• SMILES: [2H]C([2H])(C([2H])([2H])O)NCCNC1=C2C(=C(C=C1)NCCNC([2H])([2H])C([2H])([2H])O)C(=O)C3=C(C=CC(=C3C2=O)O)O

Mitoxantrone-d8 is a deuterated form of mitoxantrone, an anthracenedione chemotherapy drug used to treat various cancers, including leukemia and breast cancer. The eight deuterium atoms replace hydrogen atoms in the molecule, providing a stable isotopic label for enhanced accuracy in pharmacokinetic studies. This compound is particularly useful in tracking the drug’s absorption, distribution, metabolism, and excretion in clinical research. Mitoxantrone-d8 aids in understanding drug behavior and interactions, optimizing dosing regimens, and developing more effective cancer therapies. Its applications are crucial in pharmaceutical research, medicinal chemistry, and drug development.