For research use only. Not for therapeutic Use.
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].
Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation[1].
| Catalog Number | I019440 |
| CAS Number | 1893415-00-3 |
| Synonyms | 2,2-difluoro-N-[(1R,2S)-3-methyl-1-[1-(1-methyl-6-oxopyridin-3-yl)indazol-5-yl]oxy-1-phenylbutan-2-yl]propanamide |
| Molecular Formula | C27H28F2N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1 |
| InChIKey | ZQFNDBISEYQVRR-LOSJGSFVSA-N |
| SMILES | CC(C)C(C(C1=CC=CC=C1)OC2=CC3=C(C=C2)N(N=C3)C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F |
| Reference | [1]. Ripa L, et al. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J Med Chem. 2018 Mar 8;61(5):1785-1799. |
