Mizoribine

• CAT Number: A000603
• CAS Number: 50924-49-7
• Molecular Formula: C9H13N3O6
• Molecular Weight: 259.22
• Purity: ≥95%
• Synonyms: 50924-49-7; Bredinin; Bredinine; Mizoribinum; Mizoribina
• Target: HCV
• Solubility: Limited solubility
• Storage: -20°C
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide
• InChI: InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
• InChIKey: HZQDCMWJEBCWBR-UUOKFMHZSA-N
• SMILES: C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)N

Mizoribine（Cat No.:A000603）is an immunosuppressive agent derived from Eupenicillium brefeldianum, primarily used to inhibit purine synthesis. It selectively targets inosine monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase, enzymes essential for the de novo synthesis of guanine nucleotides. By suppressing lymphocyte proliferation, Mizoribine is effective in managing autoimmune diseases and preventing organ transplant rejection. It has a favorable safety profile compared to other immunosuppressants, reducing risks of severe infections. Mizoribine continues to be studied for its potential in treating inflammatory and immune-mediated disorders.

Reference

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2: Nishioka T, Yoshimura N, Ushigome H, Watarai Y, Nishimura K, Akioka K,
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3: Tajiri H, Zen Y, Takano T, Brooks S. Favorable response to immunosuppressive
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4: Takeuchi T, Okada K, Yoshida H, Yagi N. Post-marketing surveillance study of
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7: Ikeda K, Watanabe K, Hirai T, Tanji K, Miyashita T, Nakajima S, Uomori K,
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8: Mima A. Efficacy of mizoribine and prednisolone combination therapy in adult
patients with IgA vasculitis. Rheumatol Int. 2017 Aug;37(8):1387-1393. doi:
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9: Camero M, Buonavoglia D, Lucente MS, Losurdo M, Crescenzo G, Trerotoli P,
Casalino E, Martella V, Elia G, Tempesta M. Enhancement of the antiviral activity
against caprine herpesvirus type 1 of Acyclovir in association with Mizoribine.
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10: Sakurai K, Kubo K, Kanda H, Fujio K, Yamamoto K. Efficacy of combination
therapy with tacrolimus and mizoribine for cyclophosphamide-resistant
ANCA-associated glomerulonephritis. Int J Rheum Dis. 2017 Feb 16. doi:
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