Mizoribine

• CAT Number: A000603
• CAS Number: 50924-49-7
• Molecular Formula: C9H13N3O6
• Molecular Weight: 259.22
• Purity: ≥95%
• Synonyms: 50924-49-7; Bredinin; Bredinine; Mizoribinum; Mizoribina
• Target: IMPDH
• Solubility: Limited solubility
• Storage: -20°C
• InChI: 1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
• InChIKey: HZQDCMWJEBCWBR-UUOKFMHZSA-N
• SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N

Mizoribine,Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug. The compound was first observed in Tokyo, Japan, in 1971. It is a natural product, first isolated from the mould Eupenicillium brefeldianum. Mizoribine (MZB) is an imidazole nucleoside that has been used in renal transplantation, and in steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases.

Reference

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treatment using the purine-synthesis inhibitor mizoribine in a patient with
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2: Nishioka T, Yoshimura N, Ushigome H, Watarai Y, Nishimura K, Akioka K,
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3: Tajiri H, Zen Y, Takano T, Brooks S. Favorable response to immunosuppressive
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4: Takeuchi T, Okada K, Yoshida H, Yagi N. Post-marketing surveillance study of
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5: Hirai K, Ookawara S, Kitano T, Miyazawa H, Ito K, Ueda Y, Kaku Y, Hoshino T,
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Y. Efficacy and safety of adding mizoribine to standard treatment in patients
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6: Harada S, Nakamura T, Ushigome H, Akutsu N, Akioka K, Nakatani T, Yoshimura N.
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7: Ikeda K, Watanabe K, Hirai T, Tanji K, Miyashita T, Nakajima S, Uomori K,
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8: Mima A. Efficacy of mizoribine and prednisolone combination therapy in adult
patients with IgA vasculitis. Rheumatol Int. 2017 Aug;37(8):1387-1393. doi:
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9: Camero M, Buonavoglia D, Lucente MS, Losurdo M, Crescenzo G, Trerotoli P,
Casalino E, Martella V, Elia G, Tempesta M. Enhancement of the antiviral activity
against caprine herpesvirus type 1 of Acyclovir in association with Mizoribine.
Res Vet Sci. 2017 Apr;111:120-123. doi: 10.1016/j.rvsc.2017.02.012. Epub 2017 Feb
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10: Sakurai K, Kubo K, Kanda H, Fujio K, Yamamoto K. Efficacy of combination
therapy with tacrolimus and mizoribine for cyclophosphamide-resistant
ANCA-associated glomerulonephritis. Int J Rheum Dis. 2017 Feb 16. doi:
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