For research use only. Not for therapeutic Use.
MJN228 is a lipid-binding protein nucleobindin-1 (NUCB1) inhibitor with an IC50 of 3.3 μM[1].
MJN228 (25 μM) produces substantial reductions in lipid probe enrichment of NUCB1 in Neuro2a cells[1].
MJN228 perturbs multiple lipid pathways in cells[1].
| Catalog Number | R034322 |
| CAS Number | 459168-97-9 |
| Synonyms | (4-methylpiperazin-1-yl)-(5-nitro-3-phenyl-1H-indol-2-yl)methanone |
| Molecular Formula | C20H20N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20N4O3/c1-22-9-11-23(12-10-22)20(25)19-18(14-5-3-2-4-6-14)16-13-15(24(26)27)7-8-17(16)21-19/h2-8,13,21H,9-12H2,1H3 |
| InChIKey | BLSWPPPBUQFKHH-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C(=O)C2=C(C3=C(N2)C=CC(=C3)[N+](=O)[O-])C4=CC=CC=C4 |
| Reference | [1]. Niphakis MJ, et al. A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. |
