MK-0773

• CAT Number: I004282
• CAS Number: 606101-58-0
• Molecular Formula: C27H34FN5O2
• Molecular Weight: 479.59
• Purity: ≥95%
• Synonyms: (1S,3aS,3bS,5aR,9aS,9bS,11aS)-8-fluoro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
• Target: Androgen Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 6.6 nM [1]
• InChI: InChI=1S/C27H34FN5O2/c1-26-11-10-17-15(6-9-21-27(17,2)13-19(28)25(35)33(21)3)16(26)7-8-18(26)24(34)30-14-22-31-20-5-4-12-29-23(20)32-22/h4-5,12-13,15-18,21H,6-11,14H2,1-3H3,(H,30,34)(H,29,31,32)/t15-,16-,17-,18+,21+,26-,27+/m0/s1
• InChIKey: GBEUKTWTUSPHEE-JWJWXJQQSA-N
• SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NCC4=NC5=C(N4)C=CC=N5)CC[C@@H]6[C@@]3(C=C(C(=O)N6C)F)C

MK-0773 (CAT: I004282) is a selective androgen receptor modulator (SARM) and 4-aza-steroid that exhibits potent tissue selectivity, with an IC50 of 6.6 nM. By selectively activating androgen receptors, MK-0773 promotes anabolic effects in muscle and bone while minimizing androgenic effects in other tissues, making it a promising candidate for treating conditions like muscle wasting and osteoporosis. Its tissue-specific activity is particularly significant in endocrinology and musculoskeletal research, where it supports the development of therapies targeting age-related or disease-associated muscle and bone loss. MK-0773 offers a novel approach to androgen receptor modulation with a favorable safety profile.