MK-2048

• CAT Number: I005234
• CAS Number: 869901-69-9
• Molecular Formula: C21H21ClFN5O4
• Molecular Weight: 461.87
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CCN1CC(N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C

MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.

Reference

[1] Quashie PK, et al. J Virol. 2012, 86(5), 2696-2705.
[2] Bar-Magen T, et al. Retrovirology. 2009, 6, 103.
[3] Hare S, et al. Proc Natl Acad Sci U S A. 2010, 107(46), 20057-20062.
[4] Bar-Magen T, et al. J Virol. 2010, 84(18), 9210-9216.