MK 3118

• CAT Number: I008058
• CAS Number: 1207753-03-4
• Molecular Formula: C44H67N5O4
• Molecular Weight: 730.05
• Purity: 98%
• Synonyms: MK-3118; SCY-078; MK3118; SCY078; MK 3118; SCY 078;2-(2-amino-2,3,3-trimethylbutoxy)-1,6a,8,10a-tetramethyl-8-(3-methylbutan-2-yl)-3-(5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymeth
• Target: glucan synthase inhibitor
• Target Protein: P40989,P06780
• Solubility: Soluble in DMSO
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IUPAC Name: (1R,5S,6R,7R,10R,11R,14R,15S,20R,21R)-21-[(2R)-2-amino-2,3,3-trimethylbutoxy]-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-20-(5-pyridin-4-yl-1,2,4-triazol-1-yl)-17-oxapentacyclo[13.3.3.01,14.02,11.05,10]henicos-2-ene-6-carboxylic acid
• InChI: InChI=1S/C44H67N5O4/c1-27(2)28(3)39(7)18-19-41(9)30-12-13-33-40(8)23-52-25-44(33,31(30)14-17-42(41,10)34(39)37(50)51)22-32(35(40)53-24-43(11,45)38(4,5)6)49-36(47-26-48-49)29-15-20-46-21-16-29/h14-16,20-21,26-28,30,32-35H,12-13,17-19,22-25,45H2,1-11H3,(H,50,51)/t28-,30+,32-,33+,34-,35+,39-,40-,41-,42+,43+,44+/m1/s1
• InChIKey: BODYFEUFKHPRCK-ZCZMVWJSSA-N
• SMILES: C[C@H](C(C)C)[C@]1(CC[C@@]2([C@H]3CC[C@H]4[C@]5(COC[C@]4(C3=CC[C@]2([C@@H]1C(=O)O)C)C[C@H]([C@@H]5OC[C@@](C)(C(C)(C)C)N)N6C(=NC=N6)C7=CC=NC=C7)C)C)C

MK-3118（Cat No.:I008058）is an investigational antifungal agent belonging to the glucan synthase inhibitor class, designed to target fungal cell wall synthesis. It inhibits β-(1,3)-D-glucan synthase, an enzyme critical for the formation of fungal cell walls, leading to cell death. MK-3118 shows activity against a range of fungal pathogens, including drug-resistant strains of Candida and Aspergillus, making it a promising candidate for treating invasive fungal infections. Its unique mechanism of action offers potential advantages over existing antifungals, particularly in combating resistance in immunocompromised patients.