MK 3118

For research use only, not for therapeutic use.

  • CAT Number: I008058
  • CAS Number: 1207753-03-4
  • Molecular Formula: C44H67N5O4
  • Molecular Weight: 730.05
  • Purity: 98%
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MK-3118(Cat No.:I008058)is an investigational antifungal agent belonging to the glucan synthase inhibitor class, designed to target fungal cell wall synthesis. It inhibits β-(1,3)-D-glucan synthase, an enzyme critical for the formation of fungal cell walls, leading to cell death. MK-3118 shows activity against a range of fungal pathogens, including drug-resistant strains of Candida and Aspergillus, making it a promising candidate for treating invasive fungal infections. Its unique mechanism of action offers potential advantages over existing antifungals, particularly in combating resistance in immunocompromised patients.


Catalog Number I008058
CAS Number 1207753-03-4
Synonyms

MK-3118; SCY-078; MK3118; SCY078; MK 3118; SCY 078;2-(2-amino-2,3,3-trimethylbutoxy)-1,6a,8,10a-tetramethyl-8-(3-methylbutan-2-yl)-3-(5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymeth

Molecular Formula C44H67N5O4
Purity 98%
Target glucan synthase inhibitor
Target Protein

P40989,P06780

Solubility Soluble in DMSO
Appearance Solid
Storage Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
IUPAC Name (1R,5S,6R,7R,10R,11R,14R,15S,20R,21R)-21-[(2R)-2-amino-2,3,3-trimethylbutoxy]-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-20-(5-pyridin-4-yl-1,2,4-triazol-1-yl)-17-oxapentacyclo[13.3.3.01,14.02,11.05,10]henicos-2-ene-6-carboxylic acid
InChI InChI=1S/C44H67N5O4/c1-27(2)28(3)39(7)18-19-41(9)30-12-13-33-40(8)23-52-25-44(33,31(30)14-17-42(41,10)34(39)37(50)51)22-32(35(40)53-24-43(11,45)38(4,5)6)49-36(47-26-48-49)29-15-20-46-21-16-29/h14-16,20-21,26-28,30,32-35H,12-13,17-19,22-25,45H2,1-11H3,(H,50,51)/t28-,30+,32-,33+,34-,35+,39-,40-,41-,42+,43+,44+/m1/s1
InChIKey BODYFEUFKHPRCK-ZCZMVWJSSA-N
SMILES C[C@H](C(C)C)[C@]1(CC[C@@]2([C@H]3CC[C@H]4[C@]5(COC[C@]4(C3=CC[C@]2([C@@H]1C(=O)O)C)C[C@H]([C@@H]5OC[C@@](C)(C(C)(C)C)N)N6C(=NC=N6)C7=CC=NC=C7)C)C)C

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