MK-3207 Hydrochloride

• CAT Number: I005674
• CAS Number: 957116-20-0
• Molecular Formula: C31H29F2N5O3.HCl
• Molecular Weight: 594.05
• Purity: ≥95%
• Synonyms: MK-3207；MK3207；
• Target: Neuronal Signaling
• Solubility: DMSO ≥114mg/mL Water ≥4.6mg/mL Ethanol ≥115mg/mL
• Storage: 3 years -20C powder
• IC50: 0.024 nM (Ki, Human CGRP)
• IUPAC Name: 2-[(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]acetamide;hydrochloride
• InChI: InChI=1S/C31H29F2N5O3.ClH/c32-21-10-19(11-22(33)13-21)25-16-35-31(7-1-2-8-31)29(41)38(25)17-26(39)36-23-6-5-18-14-30(15-20(18)12-23)24-4-3-9-34-27(24)37-28(30)40;/h3-6,9-13,25,35H,1-2,7-8,14-17H2,(H,36,39)(H,34,37,40);1H/t25-,30+;/m0./s1
• InChIKey: VWKNXYACOMQRBX-KZCKSIIFSA-N
• SMILES: C1CCC2(C1)C(=O)N([C@@H](CN2)C3=CC(=CC(=C3)F)F)CC(=O)NC4=CC5=C(C[C@@]6(C5)C7=C(NC6=O)N=CC=C7)C=C4.Cl

MK-3207 hydrochloride（Cat No.:I005674）is an investigational small molecule and a selective antagonist of the CGRP (calcitonin gene-related peptide) receptor. CGRP is involved in the pathophysiology of migraine headaches by promoting vasodilation and inflammation in the brain. MK-3207 aims to block CGRP signaling, which may reduce the frequency and severity of migraine attacks. It is being studied in clinical trials as a potential treatment for migraines and other CGRP-related conditions. Early results have shown promise, but the compound’s safety, efficacy, and long-term outcomes are still being evaluated in ongoing trials.