For research use only. Not for therapeutic Use.
MK-3207 (CAT: I008059) is a potent and orally active calcitonin gene-related peptide (CGRP) receptor antagonist. It acts by binding to the CGRP receptor with high affinity (Ki = 0.024 nM), effectively blocking the interaction of CGRP with its receptor. CGRP is a neuropeptide involved in the pathophysiology of migraine, and CGRP receptor antagonists have shown efficacy in the acute treatment of migraines. MK-3207 has the potential to provide relief from migraine symptoms by inhibiting CGRP signaling and reducing the associated neurogenic inflammation.
| Catalog Number | I008059 |
| CAS Number | 957118-49-9 |
| Synonyms | MK-3207; MK3207; MK 3207;2-(8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-(2/’-oxo-1,1/’,2/’,3-tetrahydrospiro[indene-2,3/’-pyrrolo[2,3-b]pyridin]-5-yl)acetamide |
| Molecular Formula | C31H29F2N5O3 |
| Purity | ≥95% |
| Target | CGRP |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| InChI | InChI=1S/C31H29F2N5O3/c32-21-10-19(11-22(33)13-21)25-16-35-31(7-1-2-8-31)29(41)38(25)17-26(39)36-23-6-5-18-14-30(15-20(18)12-23)24-4-3-9-34-27(24)37-28(30)40/h3-6,9-13,25,35H,1-2,7-8,14-17H2,(H,36,39)(H,34,37,40) |
| InChIKey | AZAANWYREOQRFB-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC2=C(CC3(C4=CC=CN=C4NC3=O)C2)C=C1)CN(C5=O)C(C6=CC(F)=CC(F)=C6)CNC75CCCC7 |
| Reference | <br /> |
