For research use only. Not for therapeutic Use.
MK-3328 is an investigational antifungal agent that inhibits β-1,3-glucan synthase, an enzyme critical for fungal cell wall synthesis. By disrupting this process, MK-3328 weakens the cell wall, leading to the death of fungal cells. It has demonstrated efficacy against a variety of fungal pathogens, including Candida species, and is particularly valuable in cases where resistance to traditional antifungals, such as azoles and echinocandins, poses a challenge. MK-3328’s unique mechanism of action and broad-spectrum activity make it a promising candidate for treating both invasive and drug-resistant fungal infections.
| Catalog Number | I008061 |
| CAS Number | 1201323-97-8 |
| Synonyms | 5-fluoro-2-(1-methylpyrrolo[2,3-b]pyridin-5-yl)-[1,3]oxazolo[5,4-b]pyridine |
| Molecular Formula | C14H9FN4O |
| Purity | ≥95% |
| InChI | InChI=1S/C14H9FN4O/c1-19-5-4-8-6-9(7-16-12(8)19)13-17-10-2-3-11(15)18-14(10)20-13/h2-7H,1H3 |
| InChIKey | WYQHKOHCTMNFAU-UHFFFAOYSA-N |
| SMILES | CN1C=CC2=CC(=CN=C21)C3=NC4=C(O3)N=C(C=C4)F |
