For research use only. Not for therapeutic Use.
MK-467 (Cat.No:I008067) is a peripheral α2 -adrenoceptor antagonist. MK-467 dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. MK-467 may be useful in attenuating reductions in heart rates alongside dexmedetomidine.
| Catalog Number | I008067 |
| CAS Number | 130466-38-5 |
| Synonyms | MK467; MK 467; MK-467;N-(2-((2R,12bS)-2/’-oxo-1,3,4,6,7,12b-hexahydrospiro[benzofuro[2,3-a]quinolizine-2,4/’-imidazolidin]-3/’-yl)ethyl)methanesulfonamide hydrochloride |
| Molecular Formula | C20H27ClN4O4S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | N-[2-[(2R,12bS)-2/'-oxospiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,5/'-imidazolidine]-1/'-yl]ethyl]methanesulfonamide;hydrochloride |
| InChI | InChI=1S/C20H26N4O4S.ClH/c1-29(26,27)22-8-11-24-19(25)21-13-20(24)7-10-23-9-6-15-14-4-2-3-5-17(14)28-18(15)16(23)12-20;/h2-5,16,22H,6-13H2,1H3,(H,21,25);1H/t16-,20+;/m0./s1 |
| InChIKey | UTMOWVIYZQWJHT-VASSOYJASA-N |
| SMILES | CS(=O)(=O)NCCN1C(=O)NCC12CCN3CCC4=C(C3C2)OC5=CC=CC=C45.Cl |
| Reference | </br>1:The effect of MK-467, a peripheral α<sub>2</sub>-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia after intravenous administration in conscious cats. Honkavaara J, Pypendop B, Turunen H, Ilkiw J.Vet Anaesth Analg. 2017 Feb 22. pii: S1467-2987(16)31387-3. doi: 10.1111/vaa.12385. [Epub ahead of print] PMID: 28237683 </br>2:Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats. Pypendop BH, Honkavaara J, Ilkiw JE.Vet Anaesth Analg. 2017 Jan;44(1):52-62. doi: 10.1111/vaa.12397. Epub 2017 Feb 23. PMID: 27377604 </br>3:The effect of MK-467, a peripheral α<sub>2</sub> -adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia after intravenous administration in conscious cats. Honkavaara J, Pypendop B, Turunen H, Ilkiw J.Vet Anaesth Analg. 2016 May 30. doi: 10.1111/vaa.12385. [Epub ahead of print] PMID: 27238447 </br>4:Clinical effects and pharmacokinetic variables of romifidine and the peripheral α<sub>2</sub> -adrenoceptor antagonist MK-467 in horses. de Vries A, Pakkanen SA, Raekallio MR, Ekiri A, Scheinin M, Taylor PM, Vainio OM.Vet Anaesth Analg. 2016 Nov;43(6):599-610. doi: 10.1111/vaa.12354. Epub 2016 Feb 26. PMID: 26918855 </br>5:Pharmacokinetics of dexmedetomidine, MK-467, and their combination following intravenous administration in male cats. Pypendop BH, Honkavaara J, Ilkiw JE.J Vet Pharmacol Ther. 2016 Oct;39(5):460-8. doi: 10.1111/jvp.12302. Epub 2016 Feb 20. PMID: 26896345 Free Article</br>6:Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs. Bennett RC, Salla KM, Raekallio MR, Hänninen L, Rinne VM, Scheinin M, Vainio OM.J Vet Pharmacol Ther. 2016 Aug;39(4):336-43. doi: 10.1111/jvp.12292. Epub 2016 Jan 14. PMID: 26763145 </br>7:The impact of medetomidine on the protein-binding characteristics of MK-467 in canine plasma. Bennett RC, Hokkanen J, Raekallio MR, Vainio OM.J Vet Pharmacol Ther. 2016 Aug;39(4):405-7. doi: 10.1111/jvp.12291. Epub 2016 Jan 14. PMID: 26763140 </br>8:Potentiation of Glibenclamide Hypoglycaemia in Mice by MK-467, a Peripherally Acting Alpha2-Adrenoceptor Antagonist. Ruohonen ST, Ranta-Panula V, Bastman S, Chrusciel P, Scheinin M, Streng T.Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):392-8. doi: 10.1111/bcpt.12440. Epub 2015 Jul 30. PMID: 26132275 Free Article</br>9:Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane. Pakkanen SA, Raekallio MR, Mykkänen AK, Salla KM, de Vries A, Vuorilehto L, Scheinin M, Vainio OM.Vet Anaesth Analg. 2015 Sep;42(5):527-36. doi: 10.1111/vaa.12238. Epub 2014 Dec 22. PMID: 25529045 </br>10:Haemodynamic interactions of medetomidine and the peripheral alpha-2 antagonist MK-467 during step infusions in isoflurane-anaesthetised dogs. Kaartinen J, del Castillo JR, Salla K, Troncy E, Raekallio MR, Vainio OM.Vet J. 2014 Nov;202(2):353-60. doi: 10.1016/j.tvjl.2014.08.019. Epub 2014 Aug 22. PMID: 25201249 |
