MK-5172 potassium salt

• CAT Number: I000765
• CAS Number: 1206524-86-8
• Molecular Formula: C38H50KN6O9S+
• Molecular Weight: 806.00
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 7.4 nM and 7 nM for genotype 1b and 1a respectively, in replicon system
• IUPAC Name: potassium;[(1R,2S)-1-[[(1R,18R,20R,24S,27S)-24-tert-butyl-7-methoxy-22,25-dioxo-2,21-dioxa-4,11,23,26-tetrazapentacyclo[24.2.1.03,12.05,10.018,20]nonacosa-3,5(10),6,8,11-pentaene-27-carbonyl]amino]-2-ethenylcyclopropanecarbonyl]-cyclopropylsulfonylazanide
• InChI: InChI=1S/C38H50N6O9S.K/c1-6-22-19-38(22,35(47)43-54(49,50)25-13-14-25)42-32(45)29-18-24-20-44(29)34(46)31(37(2,3)4)41-36(48)53-30-16-21(30)10-8-7-9-11-27-33(52-24)40-28-17-23(51-5)12-15-26(28)39-27;/h6,12,15,17,21-22,24-25,29-31H,1,7-11,13-14,16,18-20H2,2-5H3,(H3,41,42,43,45,47,48);/q;+1/p-1/t21-,22-,24-,29+,30-,31-,38-;/m1./s1
• InChIKey: MVOGOEKATQJYHW-CIAYNJNFSA-M
• SMILES: CC(C)(C)[C@H]1C(=O)N2C[C@@H](C[C@H]2C(=O)N[C@@]3(C[C@H]3C=C)C(=O)[N-]S(=O)(=O)C4CC4)OC5=NC6=C(C=CC(=C6)OC)N=C5CCCCC[C@@H]7C[C@H]7OC(=O)N1.[K+]

MK-5172 Potassium Salt（Cat No.:I000765）is a high-purity inhibitor of hepatitis C virus (HCV) NS3/4A protease, playing a pivotal role in antiviral drug discovery. With its potent activity, it is widely employed in the development of therapies targeting HCV infection. MK-5172’s specificity for the NS3/4A protease ensures effective inhibition of viral replication, making it an invaluable tool in virology and pharmaceutical research. Its stable potassium salt form enhances solubility and consistency, ideal for various experimental setups. MK-5172 Potassium Salt is essential for advancing HCV treatment strategies and exploring protease inhibitor mechanisms.

Reference

[1]. Steven Harper , John A. McCauley , Michael T. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med. Chem. Lett., 2012, 3 (4), pp 332-336
[2]. Summa V, Ludmerer SW, McCauley JA, MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.