For research use only. Not for therapeutic Use.
MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs[1].
| Catalog Number | I046239 |
| CAS Number | 1841078-87-2 |
| Synonyms | 6-fluoro-3-pyrrolo[2,3-c]pyridin-1-ylisoquinolin-5-amine |
| Molecular Formula | C16H11FN4 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H11FN4/c17-13-2-1-11-8-20-15(7-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2 |
| InChIKey | KAXAUWZJVWGFDO-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C2=CC(=NC=C21)N3C=CC4=C3C=NC=C4)N)F |
| Reference | [1]. Walji AM, et al. Discovery of 6-(Fluoro-(18)F)-3- (1H-pyrrolo [2,3-c]pyridin-1-yl) isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 May 26;59(10):4778-89. |
