(+)-MK 801 Maleate

• CAT Number: I004841
• CAS Number: 77086-22-7
• Molecular Formula: C16H15N • C4H4O4
• Molecular Weight: 337.40
• Purity: ≥95%
• Synonyms: (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate
• Target: Membrane Transporter/Ion Channel
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: 30.5 nM[1].
• IUPAC Name: (Z)-but-2-enedioic acid;(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene
• InChI: 1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
• InChIKey: QLTXKCWMEZIHBJ-PJGJYSAQSA-N
• SMILES: C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

(+)-MK 801 Maleate(Cat No.: I004841), also known as Dizocilpine maleate, is a potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It binds within the NMDA receptor channel, blocking calcium influx and inhibiting excitatory neurotransmission. Widely used in neuroscience research, (+)-MK 801 is valuable for studying excitotoxicity, neurodegenerative diseases, and schizophrenia models. Its effects on learning, memory, and synaptic plasticity provide insights into central nervous system function. The maleate salt enhances solubility for in vivo and in vitro experimental applications.

Reference

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