For research use only. Not for therapeutic Use.
MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1].
MK-8189 (0.25-0.75 mg/kg; po) attenuates rats’ locomotor activity in a dose-dependent manner[1].
| Catalog Number | I041704 |
| CAS Number | 1424371-93-6 |
| Synonyms | 2-methyl-6-[[(1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl]methoxy]-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrimidin-4-amine |
| Molecular Formula | C19H22N6OS |
| Purity | ≥95% |
| InChI | InChI=1S/C19H22N6OS/c1-11-4-5-16(20-8-11)15-6-14(15)10-26-18-7-17(22-12(2)23-18)21-9-19-25-24-13(3)27-19/h4-5,7-8,14-15H,6,9-10H2,1-3H3,(H,21,22,23)/t14-,15+/m1/s1 |
| InChIKey | WQKPZDLZRFTMTI-CABCVRRESA-N |
| SMILES | CC1=CN=C(C=C1)C2CC2COC3=NC(=NC(=C3)NCC4=NN=C(S4)C)C |
| Reference | [1]. Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66(2):1157-1171. |
