For research use only. Not for therapeutic Use.
MK-8245 (Cat.No:I000183) is a potent and selective liver-specific thyroid hormone receptor-β (THR-β) agonist. It is being investigated for its potential use in the treatment of dyslipidemia and metabolic disorders. MK-8245 works by activating THR-β in the liver, which leads to improved lipid metabolism and regulation of glucose levels in the body.
| Catalog Number | I000183 |
| CAS Number | 1030612-90-8 |
| Synonyms | 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid |
| Molecular Formula | C17H16BrFN6O4 |
| Purity | ≥95% |
| Target | Stearoyl-CoA Desaturase (SCD) |
| Solubility | DMSO: ≤ 19 mg/mL |
| Storage | 3 years -20℃ powder |
| IC50 | 1 nM (hSCD1) [1] |
| IUPAC Name | 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid |
| InChI | InChI=1S/C17H16BrFN6O4/c18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27) |
| InChIKey | UJEAABFSXKCSGI-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1OC2=C(C=CC(=C2)F)Br)C3=NOC(=C3)C4=NN(N=N4)CC(=O)O |
| Reference | <p style=/line-height:25px/> |
