MK-886

• CAT Number: I000650
• CAS Number: 118414-82-7
• Molecular Formula: C27H34ClNO2S
• Molecular Weight: 472.10
• Purity: ≥95%
• Synonyms: MK886;MK 886
• Target: 5-Lipoxygenase
• Solubility: DMSO ≥ 32 mg/mL
• Storage: Store at RT
• IC50: 2.5 nM ( leukotriene ,LT )
• IUPAC Name: 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid
• InChI: InChI=1S/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31)
• InChIKey: QAOAOVKBIIKRNL-UHFFFAOYSA-N
• SMILES: OC(C(C)(C)CC1=C(SC(C)(C)C)C(C=C(C(C)C)C=C2)=C2N1CC3=CC=C(Cl)C=C3)=O

MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP), a key enzyme involved in the synthesis of leukotrienes, which are inflammatory mediators. By inhibiting FLAP, MK-886 effectively reduces leukotriene production, making it a promising compound for the treatment of inflammatory diseases such as asthma, allergic rhinitis, and atherosclerosis. Its ability to modulate the leukotriene pathway is critical in exploring new therapeutic strategies for conditions involving excessive inflammation.