MK2-IN-1 hydrochloride

• CAT Number: I001206
• CAS Number: 1314118-94-9
• Molecular Formula: C27H25ClN4O2 • HCl
• Molecular Weight: 509.4
• Purity: ≥95%
• Synonyms: 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide, monohydrochloride
• Target: MKK
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.11 uM [1]
• InChIKey: AZDOSXSDARWKGX-UHFFFAOYSA-N

MK2-IN-1 hydrochloride (CAT: I001206) emerges as a potent and selective inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2). This compound demonstrates robust inhibitory activity against MK2, with an impressive IC50 value of 0.11 μM. Notably, its mechanism of action involves a non-ATP competitive binding mode, allowing for specific modulation of MK2 activity without targeting the ATP binding site. This unique binding mode contributes to its selectivity and potential for therapeutic application.

Reference

[1]. Rao AU, et al. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.
[2]. Huang X, et al. A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.
[3]. Huang X, et al. Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.