MK2-IN-5 acetate

• CAT Number: I040101
• Molecular Formula: C61H113N21O16.xC2H4O2
• Molecular Weight: 1396.68 (free base)
• Purity: ≥95%

MK2-IN-5 acetate (Cat No.: I040101) is a selective small-molecule inhibitor of MAPK-activated protein kinase 2 (MK2), an enzyme involved in the regulation of inflammatory responses, stress signaling, and cytokine production. By targeting MK2, this compound modulates the p38 MAPK pathway, making it a promising candidate for treating inflammatory and autoimmune diseases. MK2-IN-5 acetate has shown potential in preclinical models for reducing the expression of pro-inflammatory mediators such as TNF-α. It is primarily used in research exploring kinase-targeted therapies and stress-related cellular mechanisms.

Reference

[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480.
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[2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600.
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[3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539.
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