MK6-83

For research use only. Not for therapeutic Use.

  • CAT Number: R028305
  • CAS Number: 1062271-24-2
  • Molecular Formula: C16H20N2O2S2
  • Molecular Weight: 336.47
  • Purity: ≥95%
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MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1].
MK6-83 2 ranging from 0.2 to 30 μM shows no signs of cytotoxicity[1].
MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells[1].


Catalog Number R028305
CAS Number 1062271-24-2
Synonyms

5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide

Molecular Formula C16H20N2O2S2
Purity ≥95%
InChI InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
InChIKey IRGYSXZCDAWOOC-UHFFFAOYSA-N
SMILES CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
Reference

[1]. Cheng-Chang Chen, et al. A Small Molecule Restores Function to TRPML1 Mutant Isoforms Responsible for Mucolipidosis Type IV. Nat Commun. 2014 Aug 14;5:4681.
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