For research use only. Not for therapeutic Use.
MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1].
MK6-83 2 ranging from 0.2 to 30 μM shows no signs of cytotoxicity[1].
MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells[1].
Catalog Number | R028305 |
CAS Number | 1062271-24-2 |
Synonyms | 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide |
Molecular Formula | C16H20N2O2S2 |
Purity | ≥95% |
InChI | InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3 |
InChIKey | IRGYSXZCDAWOOC-UHFFFAOYSA-N |
SMILES | CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3 |
Reference | [1]. Cheng-Chang Chen, et al. A Small Molecule Restores Function to TRPML1 Mutant Isoforms Responsible for Mucolipidosis Type IV. Nat Commun. 2014 Aug 14;5:4681. |