For research use only. Not for therapeutic Use.
MKC8866(CAT: I019947) is a potent and selective inhibitor of IRE1α RNase activity, widely utilized in research on endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). By specifically targeting the RNase domain of IRE1α, it blocks the splicing of XBP1 mRNA, a key event in the UPR pathway. MKC8866 is instrumental in studying the role of ER stress in cancer, neurodegenerative diseases, and metabolic disorders. With high specificity and stability, it is ideal for in vitro and in vivo studies, supporting the exploration of therapeutic strategies aimed at modulating ER stress and UPR signaling in disease contexts.
| Catalog Number | I019947 |
| CAS Number | 1338934-59-0 |
| Molecular Formula | C₁₈H₁₉NO₇ |
| Purity | ≥95% |
| Target | IRE1 |
| IUPAC Name | 7-hydroxy-6-methoxy-4-methyl-3-(2-morpholin-4-yl-2-oxoethyl)-2-oxochromene-8-carbaldehyde |
| InChI | InChI=1S/C18H19NO7/c1-10-11-7-14(24-2)16(22)13(9-20)17(11)26-18(23)12(10)8-15(21)19-3-5-25-6-4-19/h7,9,22H,3-6,8H2,1-2H3 |
| InChIKey | IFDGMRMUJYGWQQ-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)OC2=C(C(=C(C=C12)OC)O)C=O)CC(=O)N3CCOCC3 |
