MKT 077

• CAT Number: M129784
• CAS Number: 147366-41-4
• Molecular Formula: C21H22N3OS2 • Cl
• Molecular Weight: 432.00
• Purity: ≥95%
• Synonyms: 1-ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
• Target: HSP
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at 4℃
• IUPAC Name: (2Z,5E)-3-ethyl-2-[(1-ethylpyridin-1-ium-2-yl)methylidene]-5-(3-methyl-1,3-benzothiazol-2-ylidene)-1,3-thiazolidin-4-one;chloride
• InChI: InChI=1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+
• InChIKey: VSKYOTRJSLYFHX-UXJRWBAGSA-M
• SMILES: CCN1C(=CC2=CC=CC=[N+]2CC)SC(=C3N(C4=CC=CC=C4S3)C)C1=O.[Cl-]

MKT 077（Cat No.:M129784）is a water-soluble rhodacyanine dye that selectively accumulates in the mitochondria of cancer cells, where it disrupts mitochondrial function by inhibiting heat shock protein 70 (Hsp70). This leads to mitochondrial depolarization, reduced ATP production, and apoptosis, making MKT 077 a promising anticancer agent. Its preferential targeting of cancer cell mitochondria while sparing normal cells offers a potential therapeutic advantage. MKT 077 has been studied in various cancer models, showing the ability to induce cell death in malignancies with minimal toxicity to healthy tissues.