ML-099

• CAT Number: R061166
• CAS Number: 496775-95-2
• Molecular Formula: C14H13NO2S
• Molecular Weight: 259.32
• Purity: ≥95%
• Synonyms: 2-(2-phenylethylsulfanyl)pyridine-3-carboxylic acid
• InChI: InChI=1S/C14H13NO2S/c16-14(17)12-7-4-9-15-13(12)18-10-8-11-5-2-1-3-6-11/h1-7,9H,8,10H2,(H,16,17)
• InChIKey: UZERZZRWECLIKE-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CCSC2=C(C=CC=N2)C(=O)O

ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A[1].
ML-099 activates cell division cycle 42 activated mutant, cell division cycle 42 wild type, Ras protein wild type, GTP-binding protein (Rab7), Rab-2A, Rac1 protein activated mutant, Rac1 protein wild type, and Ras protein activated mutant with EC50 values of 58.88 nM, 100 nM, 141.25 nM, 181.97 nM, 354.81 nM, 25.42 nM, 20.17 nM and 95.5 nM, respectively[1].

Reference

[1]. Surviladze, Z., et al. UNMCMD Probe Report: Three small molecule pan activator families of Ras-related GTPases. 1-42 (2010-2009 May 18).
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