ML-109

• CAT Number: I019739
• CAS Number: 1186649-91-1
• Molecular Formula: C₃₁H₂₉N₃O₅
• Molecular Weight: 523.58
• Purity: ≥95%
• Target: TSH Receptor

ML-109 (CAT: I019739) is a potent and full agonist of the thyroid-stimulating hormone receptor (TSHR). It activates the TSHR, a G-protein coupled receptor expressed in the thyroid gland, leading to the stimulation of thyroid hormone synthesis and release. ML-109 mimics the action of endogenous TSH and has been used in research to study the function of the TSHR and its downstream signaling pathways. It is valuable for investigating thyroid-related disorders and developing therapeutic strategies targeting TSHR.

Reference

[1]. Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.