For research use only. Not for therapeutic Use.
ML132(Cat No.:I008085), also known as CID-4462093 or NCGC-00183434, is a highly potent inhibitor of caspase 1, demonstrating superior activity compared to other reported caspase inhibitors. Caspase 1 is a protease involved in the inflammatory response and plays a critical role in the processing and release of pro-inflammatory cytokines. ML132 exhibits a unique selectivity profile, specifically targeting caspase 1 with high affinity while showing minimal inhibition of other caspase enzymes. This selectivity makes ML132 a valuable tool for studying the role of caspase 1 in inflammatory processes and potentially a promising candidate for therapeutic interventions in inflammatory diseases.
| Catalog Number | I008085 |
| CAS Number | 1230628-71-3 |
| Molecular Formula | C22H28ClN5O5 |
| Purity | ≥95% |
| Target | Caspase |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (3S)-3-[[(2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-cyanopropanoic acid |
| InChI | InChI=1S/C22H28ClN5O5/c1-22(2,3)18(27-19(31)12-6-7-15(25)14(23)9-12)21(33)28-8-4-5-16(28)20(32)26-13(11-24)10-17(29)30/h6-7,9,13,16,18H,4-5,8,10,25H2,1-3H3,(H,26,32)(H,27,31)(H,29,30)/t13-,16-,18+/m0/s1 |
| InChIKey | KENKPOUHXLJLEY-QANKJYHBSA-N |
| SMILES | CC(C)(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C#N)NC(=O)C2=CC(=C(C=C2)N)Cl |
| Reference | </br>1:Boxer MB, Shen M, Auld DS, Wells JA, Thomas CJ. A small molecule inhibitor of Caspase 1. 2010 Feb 25 [updated 2011 Mar 3]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK56241/PubMed PMID: 21735610. orhttp://www.ncbi.nlm.nih.gov/pubmed/21735610 |
