For research use only. Not for therapeutic Use.
ML133 HCl is a selective potassium channel inhibitor for K<sub>ir</sub>2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on K<sub>ir</sub>1.1 and weak activity for K<sub>ir</sub>4.1 and K<sub>ir</sub>7.1.<br>The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K
| Catalog Number | R058691 |
| CAS Number | 1222781-70-5 |
| Synonyms | N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine Hydrochloride; |
| Molecular Formula | C19H19NO.HCl |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
