ML-162

• CAT Number: R066776
• CAS Number: 1035072-16-2
• Molecular Formula: C23H22Cl2N2O3S
• Molecular Weight: 477.40
• Purity: ≥95%
• Synonyms: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide
• Storage: -20°C
• IUPAC Name: 2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
• InChI: InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)
• InChIKey: UNVKYJSNMVDZJE-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl

ML-162（Cat No.:R066776）is a potent small-molecule inhibitor specifically targeting mutant p53-R175H, a common mutation in the p53 tumor suppressor gene associated with various cancers. By restoring wild-type p53 function, ML-162 promotes cell cycle arrest and apoptosis in cancer cells harboring this mutation, thereby suppressing tumor growth. Its high selectivity minimizes off-target effects, making it a promising tool in targeted cancer therapies focused on p53-mutant cancers. ML-162’s potential in preclinical cancer research supports its exploration for therapeutic development, particularly in precision oncology strategies aimed at difficult-to-treat malignancies.

Reference

1.Weïwer, M.,Bittker, J.A.,Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).