ML-210

• CAT Number: I011957
• CAS Number: 1360705-96-9
• Molecular Formula: C22H20Cl2N4O4
• Molecular Weight: 475.32
• Purity: ≥95%
• Synonyms: CID 49766530; CID-49766530; CID49766530; ML-210; ML 210; ML210.;[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• Solubility: Soluble in DMSO
• Storage: Store at 2-8 °C
• IUPAC Name: [4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• InChI: InChI=1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
• InChIKey: VIBHJPDPEVVDTB-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]

ML-210（Cat No.:I011957）is a small-molecule inhibitor known for selectively targeting mutant p53, a protein frequently altered in cancer that drives tumor progression and resistance to therapy. By destabilizing mutant p53, ML-210 induces apoptosis in cancer cells reliant on aberrant p53 function, helping suppress tumor growth. Its specificity makes it a valuable compound in studying p53’s role in oncogenesis and exploring targeted cancer therapies. ML-210’s potential to modulate key apoptotic pathways positions it as a promising agent in precision oncology, particularly in cancers with p53 mutations.

Reference

1: Bittker JA, Weiwer M, Lewis T, Shimada K, Yang WS, MacPherson L, Dandapani S, Munoz B, Palmer M, Stockwell BR, Schreiber SL. Screen for RAS-Selective Lethal Compounds and VDAC Ligands – Probe 2. 2011 Feb 10 [updated 2011 Dec 12]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK98919/ PubMed PMID: 22834036.2: Devarajan R, Ashraf M, Beck RO, Lemberger RJ, Taylor MC. Holmium: YAG lasertripsy for ureteric calculi: an experience of 300 procedures. Br J Urol. 1998 Sep;82(3):342-7. PubMed PMID: 9772868.3: Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. doi: 10.1016/j.bmcl.2011.09.047. Epub 2011 Sep 28. PubMed PMID: 22297109; PubMed Central PMCID: PMC3528973.