ML 324 dihydrochloride

• CAT Number: I047592
• CAS Number: 2108968-53-0
• Molecular Formula: C21H23N3O2.2HCl
• Molecular Weight: 422.35
• Purity: ≥95%
• IUPAC Name: N-[3-(dimethylamino)propyl]-4-(8-hydroxyquinolin-6-yl)benzamide;dihydrochloride
• InChI: InChI=1S/C21H23N3O2.2ClH/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18;;/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26);2*1H
• SMILES: CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC(=C3C(=C2)C=CC=N3)O.Cl.Cl

Inhibitor of Jumonji domain-containing protein 2 (JMJD2, an “eraser”) histone demethylase; effectively blocked herpes simplex virus (HSV) IE gene expression and prevented viral reactivation from latency; >75 fold more efficient than DMOG. The free base ML 324 is available as Axon 3562.
KEYWORDS: ML 324 dihydrochloride | Supplier | JMJD2 inhibitor | ML324 | ML-324 | CAS [2108968-53-0] | [1222800-79-4] | Histone | Histone demethylase | Inhibitor | Enzymes

Reference

Y Liang et al. Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. Sci Transl Med. 2013, 5(167), 167ra5. 

 

C Harrison. Comment in Epigenetic drugs: new modulators of readers and erasers. Nat. Rev. Drug Discov. 2013, 12(3), 188.