For research use only. Not for therapeutic Use.
ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during <em>de novo</em> pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC<sub>50</sub> value of approximately 2 µM.
| Catalog Number | R066967 |
| CAS Number | 2029049-79-2 |
| Synonyms | N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-benzamide |
| Molecular Formula | C21H21F3N2O3 |
| Purity | ≥95% |
| Target | Dihydroorotate Dehydrogenase |
| Storage | -20°C |
| InChI | InChI=1S/C21H21F3N2O3/c22-21(23,24)29-16-10-8-15(9-11-16)20(28)25-13-12-19(27)26-18-7-3-5-14-4-1-2-6-17(14)18/h1-2,4,6,8-11,18H,3,5,7,12-13H2,(H,25,28)(H,26,27)/t18-/m1/s1 |
| InChIKey | SGNRHEDBLPGDDC-GOSISDBHSA-N |
| SMILES | O=C(NCCC(N[C@H]1C(C=CC=C2)=C2CCC1)=O)C3=CC=C(OC(F)(F)F)C=C3 |
| Reference | 1.Sykes, D.B.,Kfoury, Y.S.,Mercier, F.E., et al. Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell. 167(1), 171-186 (2016). |
