For research use only. Not for therapeutic Use.
ML-7 HCl（Cat No.:I000430） is a potent, reversible, and selective inhibitor of myosin light chain kinase (MLCK). It is cell-permeable and competes with ATP binding to the kinase (Ki = 300 nM). ML-7 HCl effectively inhibits both MLCK and smooth-muscle myosin light chain kinase. Additionally, it exhibits inhibitory activity against protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). The broad inhibition spectrum of ML-7 HCl makes it a valuable tool for studying cellular processes involving these kinases and has potential applications in various fields, including cell biology and pharmacology.
| Catalog Number | I000430 |
| CAS Number | 110448-33-4 |
| Synonyms | 1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride |
| Molecular Formula | C15H17IN2O2S • HCl |
| Purity | ≥95% |
| Target | Stem Cell/Wnt |
| Solubility | DMSO: ≥ 43 mg/mL |
| Storage | Store at -20°C |
| IC50 | 300 nM (Ki) |
| IUPAC Name | 1-(5-iodonaphthalen-1-yl)sulfonyl-1,4-diazepane;hydrochloride |
| InChI | InChI=1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H |
| InChIKey | KDDALCDYHZIZMH-UHFFFAOYSA-N |
| SMILES | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl |
| Reference | </br>1:Selective inhibition of collagen-induced arachidonic acid liberation by 1-(5-iodonaphthalene-1-sulphonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), a myosin light chain kinase inhibitor, in washed rabbit platelets. Matsuoka I, Nakahata N, Nakanishi H.Biochem Pharmacol. 1997 Nov 1;54(9):1019-26. PMID: 9374423 </br>2:Activity of 4/’-0-tetrahydropyranyladriamycin hydrochloride (THP-ADM) in a human tumor cloning system. Inoue K, Arakawa M, Miyamoto H, Ogawa M.Invest New Drugs. 1983;1(4):271-5. PMID: 6687222 |
