ML SA1

• CAT Number: I011015
• CAS Number: 332382-54-4
• Molecular Formula: C22H22N2O3
• Molecular Weight: 362.429
• Purity: ≥95%
• Synonyms: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
• Target: Neuronal Signaling
• Solubility: Soluble to 20 mM in DMSO
• Storage: Store at +4C
• IUPAC Name: 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione
• InChI: InChI=1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
• InChIKey: KDDHBJICVBONAX-UHFFFAOYSA-N
• SMILES: CC1CC(N(C2=CC=CC=C12)C(=O)CN3C(=O)C4=CC=CC=C4C3=O)(C)C

ML SA1 (CAT: I011015) serves as a potent activator of TRPML (transient receptor potential mucolipin) channels, including TRPML1, 2, and 3, exhibiting the ability to elicit Ca2+ release from lysosomes through TRPML-mediated mechanisms. Notably, ML SA1’s activation profile is specific to TRPML channels, as it does not engage TRPM2, TRPV2, TRPV3, TRPC6, or TRPA1 channels. Through its modulation of TRPML-mediated Ca2+ release, ML SA1 demonstrates potential therapeutic implications, as it corrects trafficking abnormalities and reduces cholesterol accumulation in macrophages associated with Niemann-Pick type C.