ML-SI3

• CAT Number: I047355
• CAS Number: 891016-02-7
• Molecular Formula: C23H31N3O3S
• Molecular Weight: 429.58
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: COC1=CC=CC=C1N2CCN(CC2)C3CCCCC3N[S](=O)(=O)C4=CC=CC=C4

ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.

Reference

[1] Philipp Rühl , et al. Sci Rep . 2021 Apr 15;11(1):8313.
[2] Ruhl P, et al. Sci Rep. 2021 Apr 15;11(1):8313.
[3 Xing Y, et al. Basic Res Cardiol. 2022 Apr 7;117(1):20.