For research use only. Not for therapeutic Use.
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia[1][2].
| Catalog Number | I044098 |
| CAS Number | 1306638-12-9 |
| Synonyms | 5-fluoro-2-phenyl-1,2-benzothiazol-3-one |
| Molecular Formula | C13H8FNOS |
| Purity | ≥95% |
| InChI | InChI=1S/C13H8FNOS/c14-9-6-7-12-11(8-9)13(16)15(17-12)10-4-2-1-3-5-10/h1-8H |
| InChIKey | ZTQXZKHEMCRFEP-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)N2C(=O)C3=C(S2)C=CC(=C3)F |
| Reference | [1]. Russell Dahl, et al. Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem. 2011 May 26;54(10):3661-8. |
