For research use only. Not for therapeutic Use.
ML130 is an inhibitor of NOD1 (nucleotide-binding oligomerization domain containing 1).
| Catalog Number | R055828 |
| CAS Number | 799264-47-4 |
| Synonyms | 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine; |
| Molecular Formula | C₁₄H₁₃N₃O₂S |
| Purity | ≥95% |
| Target | NOD-like Receptor (NLR) |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16) |
| InChIKey | SRFABRWQVPCPRG-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N |
| Reference | </br>1: Fan YH, Roy S, Mukhopadhyay R, Kapoor A, Duggal P, Wojcik GL, Pass RF, Arav-Boger R. Role of nucleotide-binding oligomerization domain 1 (NOD1) and its variants in human cytomegalovirus control in vitro and in vivo. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7818-E7827. PubMed PMID: 27856764; PubMed Central PMCID: PMC5137695.</br>2: Wei LJ, Tan X, Fan GJ, Jiang YN, Shah QA. Role of the NOD1/NF-κB pathway on bovine neutrophil responses to crude lipopolysaccharide. Vet J. 2016 Aug;214:24-31. doi: 10.1016/j.tvjl.2016.02.006. PubMed PMID: 27387722.</br></br> |
