For research use only. Not for therapeutic Use.
ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways[1].
ML148 (compound 13) shows selectivity with IC50s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively[1].
ML148 (10, 20 nM) decrease Vmax by 25% and reduces the apparent Km by half at a concentration of 10 nM[1].
| Catalog Number | R066782 |
| CAS Number | 451496-96-1 |
| Synonyms | [1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone |
| Molecular Formula | C20H21N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3 |
| InChIKey | YQNOQZALLOQMPY-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4 |
| Reference | [1]. Niesen FH, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS One. 2010 Nov 2;5(11):e13719. |
